Table 2.

Main effects of the CTQ summary score, abuse and neglect on potential mediators.

	CTQ Summary Score					CTQ Abuse					CTQ Neglect
	T0	S2	Meta-analysis			T0	S2	Meta-analysis			T0	S2	Meta-analysis
	N		β/OR	SE	p FDR	N		β/OR	SE	p FDR	N		β/OR	SE	p FDR
Systolic BP	3,507	1,635	0.034	0.028	0.217	3,507	1,635	−0.043	0.034	0.261	3,507	1,635	0.129	0.096	0.201
Hypertension	3,511	1,639	1.028	0.742	0.180	3,511	1,639	1.071	0.846	0.261	3,511	1,639	1.073	0.816	0.201
WHtR	3,505	1,637	0.035	0.013	0.022	3,505	1,637	0.073	0.052	0.256	3,505	1,637	0.094	0.040	0.045
Obesity (Yes)	3,512	1,638	1.056	0.740	0.180	3,512	1,638	1.178	0.833	0.256	3,512	1,638	1.272	0.805	0.165
Triglycerides	3,501	1,631	0.028	0.013	0.063	3,501	1,631	0.026	0.050	0.605	3,501	1,631	0.057	0.041	0.201
HDL-C	3,517	1,639	−0.030	0.013	0.038	3,517	1,639	−0.036	0.048	0.491	3,517	1,639	−0.079	0.038	0.081
Depressive Symptoms	3,472	1,640	0.260	0.013	2.51e−87	3,472	1,640	0.611	0.051	4.37e−32	3,472	1,640	0.437	0.042	1.50e−24
Mental SHC	3,387	1,574	0.254	0.016	5.45e−57	3,387	1,574	0.650	0.064	8.69e−24	3,387	1,574	0.439	0.048	3.82e−19
Somatic SHC	3,375	1,572	0.191	0.015	1.01e−35	3,375	1,572	0.432	0.058	5.51e−13	3,375	1,572	0.329	0.046	4.98e−12
Alcohol Consumption	3,483	1,530	−0.037	0.013	0.015	3,483	1,530	−0.125	0.051	0.037	3,483	1,530	−0.153	0.041	5.91e−04
Risky Alcohol Consumption (Yes)	3,483	1,530	1.103	0.761	0.180	3,483	1,530	1.153	0.941	0.261	3,483	1,530	1.125	0.879	0.201
Pack Years	1,568	751	0.080	0.018	1.99e−05	1,568	751	0.195	0.067	0.012	1,568	751	0.112	0.056	0.087
Ever-smoker (Yes)	3,504	1,636	1.204	0.740	0.150	3,504	1,636	1.690	0.843	0.097	3,504	1,636	1.498	0.811	0.105

Models were adjusted for age (non-linear) and sex.

T0, SHIP-TREND-0; S2, SHIP-START-2; FDR, false discovery rate to adjust for multiple testing; CTQ, Childhood Trauma Questionnaire.

BP, blood pressure; WHtR, waist-height ratio; HDL-C, high-density lipoprotein cholesterol; SHC, Subjective Health Complaints.