Table 3.
Main effects on serum cortisol concentrations.
| T0 | S2 | Meta-analysis | |||
|---|---|---|---|---|---|
| N | β | SE | p FDR | ||
| PREDICTORS | |||||
| CTQ Summary Score | 3,517 | 1,640 | −0.052 | 0.012 | 7.25e−05 |
| CTQ Abuse | 3,517 | 1,640 | −0.140 | 0.046 | 0.003 |
| CTQ Neglect | 3,517 | 1,640 | −0.111 | 0.037 | 0.003 |
| MEDIATORS | |||||
| Systolic BP | 3,507 | 1,635 | −0.002 | 0.004 | 0.509 |
| Hypertension | 3,511 | 1,639 | 0.103 | 0.031 | 0.001 |
| WHtR | 3,505 | 1,637 | −0.087 | 0.016 | 8.95e−08 |
| Obesity | 3,512 | 1,638 | −0.180 | 0.029 | 5.66e−09 |
| Triglycerides | 3,501 | 1,631 | 0.061 | 0.015 | 8.69e−05 |
| HDL-C | 3,517 | 1,639 | 0.108 | 0.015 | 4.02e−12 |
| Depressive Symptoms | 3,472 | 1,640 | −0.051 | 0.013 | 2.56e−04 |
| Mental SHC | 3,387 | 1,574 | −0.028 | 0.014 | 0.044 |
| Somatic SHC | 3,375 | 1,572 | −0.059 | 0.014 | 8.69e−05 |
| Alcohol Consumption | 3,483 | 1,530 | 0.089 | 0.015 | 1.23e−08 |
| Risky Alcohol Consumption | 3,483 | 1,530 | 0.273 | 0.049 | 1.01e−07 |
| Pack Years | 1,568 | 751 | −0.066 | 0.022 | 0.003 |
| Ever-smoker | 3,504 | 1,636 | −0.108 | 0.028 | 2.06e−04 |
Models were adjusted for age (non-linear), sex, fasting time (non-linear), time of blood sampling (non-linear), glycated hemoglobin and white blood cell count.
T0, SHIP-TREND-0; S2, SHIP-START-2; FDR, false discovery rate to adjust for multiple testing.
CTQ, Childhood Trauma Questionnaire; BP, blood pressure; WHtR, waist-height ratio; HDL-C, high-density lipoprotein cholesterol; SHC, Subjective Health Complaints.