Table 4.

Separate mediation analyses for the impact of the CTQ summary score, abuse and neglect on serum cortisol concentrations.

	Total Effect			Direct Effect			Indirect Effect
	β	SE	p-value	β	SE	p FDR	β	SE	p FDR	Proportion Mediated
CTQ Summary Score	−0.052	0.013	5.70e−05
WHtR				−0.050	0.013	3.11e−04	−0.002	0.001	0.229	3.14
HDL-C				−0.050	0.013	3.11e−04	−0.003	0.002	0.171	4.79
Depressive Symptoms				−0.042	0.013	0.002	−0.011	0.004	0.019	21.04
Mental SHC				−0.048	0.013	4.58e−04	−0.004	0.004	0.281	7.84
Somatic SHC				−0.043	0.013	0.001	−0.010	0.003	0.007	19.24
Alcohol Consumption				−0.049	0.013	3.11e−04	−0.002	0.001	0.146	4.04
Pack Years				−0.047	0.013	4.58e−04	−0.003	0.002	0.225	5.99
CTQ Abuse	−0.038	0.013	0.004
Depressive Symptoms				−0.030	0.013	0.023	−0.007	0.002	0.004	19.72
Mental SHC				−0.034	0.013	0.018	−0.004	0.003	0.146	10.71
Somatic SHC				−0.031	0.013	0.021	−0.006	0.002	0.004	17.22
Alcohol Consumption				−0.034	0.013	0.018	−0.002	0.001	0.146	5.00
Pack Years				−0.035	0.013	0.018	−0.002	0.002	0.322	5.24
CTQ Neglect	−0.037	0.013	0.005
WHtR				−0.035	0.013	0.023	−0.002	0.001	0.118	5.54
Depressive Symptoms				−0.030	0.013	0.023	−0.007	0.002	0.005	19.07
Mental SHC				−0.033	0.013	0.023	−0.003	0.002	0.126	9.05
Somatic SHC				−0.031	0.013	0.023	−0.006	0.002	0.005	16.87
Alcohol Consumption				−0.032	0.013	0.023	−0.003	0.001	0.023	8.29

Models were adjusted for age (non-linear), sex, fasting time (non-linear), time of blood sampling (non-linear), glycated hemoglobin and white blood cell count.

FDR, false discovery rate to adjust for multiple testing; CTQ, Childhood Trauma Questionnaire; WHtR, waist-height ratio; HDL-C, high-density lipoprotein cholesterol; SHC, Subjective Health Complaints.