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Immune factors in Pediatric Malaria: Due to lack of acquired functional immunity, Lower INF-α, impaired monocytes, Low NK cells and complement concentration, malaria susceptibility is increased in children below 5 years of age. Because of low complement concentration, the antibody-based killing of gametocytes gets hampered in children, including in older children. They can act as parasite reservoirs due to gametocyte survival for extended periods.
