Skip to main content
. 2024 Mar 4;19(3):e0294018. doi: 10.1371/journal.pone.0294018

Table 1. Dose escalation of 5-FU 24-hour EPIC for each titration level and concomitant treatment where irinotecan is also an investigational drug (the other drugs are non-investigational and given to both groups in the randomized part of the trial).

Level Non-investigational
Oxaliplatin		 Investigational
Irinotecan		 Investigational
5-FU
24-hour EPIC		 Non-investigational
5-FU
bolus		 Non-investigational
Calcium folinate
-1 360 mg/m2 360 mg/m 2 250 mg/m 2 400 mg/m2 60mg/m2
0 360 mg/m2 360 mg/m 2 400 mg/m 2 400 mg/m2 60mg/m2
1 360 mg/m2 360 mg/m 2 550 mg/m 2 400 mg/m2 60mg/m2
2 360 mg/m2 360 mg/m 2 700 mg/m 2 400 mg/m2 60mg/m2
3 360 mg/m2 360 mg/m 2 850 mg/m 2 400 mg/m2 60mg/m2