FIG. 8.

Model depicting genes involved in docking and/or fusion at the vacuole. Three vacuolar proteins proceed to the vacuole via distinct biosynthetic pathways, indicated above the arrows. Vam7p and Vam3p function as a t-SNARE complex in the docking and/or fusion of transport intermediates to the vacuole. Other genes that are proposed to regulate the docking and fusion of transport intermediates to the vacuole are enclosed by brackets. The homologies between these VPS genes and proteins implicated in vesicular docking and fusion are indicated (•). The PX domain and coiled-coil domains of Vam7p and Vam3p are also schematically diagrammed.