Table 1.
Baseline demographics and cognitive scores.
| Men (N = 77) | Women (N = 62) | Comparison | |
|---|---|---|---|
| Age at baseline visit, years | 69.1 (7.8) [51.4–85.8] | 68.4 (5.6) [54.0–84.3] | U = 2206.0, p = 0.78 |
| Age at PSP onset, years | 66.4 (8.3) [48.7–84.3] | 65.3 (5.7) [51.5–82.4] | U = 2162.5, p = 0.78 |
| Education, n | χ2 = 11.1, p = 0.62 | ||
| Able to read/write | 1 | 0 | |
| Less than elementary | 1 | 2 | |
| Elementary | 21 | 20 | |
| High school | 20 | 25 | |
| More than high school | 11 | 8 | |
| University degree | 17 | 3 | |
| Post-graduate degree | 6 | 4 | |
| Education (binarized), n | |||
| < High school | 23 | 22 | χ2 = 0.49, p = 0.79 |
| ≥ High school | 54 | 40 | |
| Number Conditions | 5.4 (3.8) [0.0–16.0] | 5.6 (3.6) [1.0–17.0] | U = 2281.0, p = 0.78 |
| Phenotype, n | χ2 = 0.90, p = 0.85 | ||
| PSP-Parkinsonism | 30 | 26 | |
| PSP-Richardson | 46 | 36 | |
| Pure akinesia with freezing gait | 1 | 0 | |
| PSPRS total | 39.2 (13.5) [9.0–67.0] | 39.3 (10.1) [10.0–64.0] | U = 2277.0, p = 0.78 |
| Disease duration, years | 2.8 (3.2) [0.03–22.8] | 3.3 (2.5) [0.12–12.3] | U = 1890.0, p = 0.28 |
| FAB | |||
| Total score | 11.0 (4.2) [0–18] | 11.6 (4.0) [3–18] | U = 2185.5, p = 0.78 |
| Corrected FAB <13.48, n | 46 | 41 | χ2 = 0.5987, p = 0.78 |
| DRS | |||
| Memory | 20.5(5.3) [5–25] | 21.0 (4.1) [12–25] | U = 2253.0, p = 0.78 |
| Attention | 32.9(4.8) [15–37] | 33.2 (4.2) [19–37] | U = 2333.5, p = 0.78 |
| Construction | 4.1 (2.0) [0–6] | 4.0 (2.3) [0–6] | U = 2321.0, p = 0.78 |
| Initiation/Perseveration | 24.2 (7.0) [4–37] | 25.2 (7.3) [8–37] | U = 2205.0, p = 0.78 |
| Conceptualization | 32.2 (6.8) [5–39] | 31.6 (6.0) [14–39] | U = 2165.0, p = 0.78 |
| Total | 114.0 (21.0) [33–144] | 115.0 (19.4) [66–142] | U = 2312.0, p = 0.78 |
| Fluency ^ | |||
| Category | 9.7 (4.5) [1.5–25.0] | 10.2 (4.5) [1.5–22.0] | U = 2241.0, p = 0.78 |
| Lexical | 4.3 (3.2) [0.0–14.5] | 5.3 (3.9) [1.5–22.0] | U = 2045.0, p = 0.16 |
Findings for continuous variables are reported as mean (SD), [minimum-maximum]. Findings for categorical variables are reported as counts. P-values are from Mann-Whitney test for continuous variables and from χ2 test for categorical variables, and are FDR-corrected. PSP: Progressive Supranuclear Palsy, PSPRS: Progressive Supranuclear Palsy Rating Scale, FAB: Frontal Assessment Battery, DRS: Dementia Rating Scale.
#
Sum across disorientation, bradyphrenia, emotional incontinence, and grasping/imitative/utilizing behavior from the PSPRS.
^
Fluency values are reported as mean across the categories “animals” and “supermarket” for category fluency, and mean across the letters “A” and “S” for lexical fluency.