Table 1.
Descriptive Statistics and Comparative Analysis of Patient Variables and Vital Status
| Variable | Levels | Total (n=1873) | Vital status | P-value | |
|---|---|---|---|---|---|
| Survived or discharged (n=1396) | Deceased (n=492) | ||||
| Age at diagnosis | ----- | 55.20 ± 14.55 | 54.82 ± 14.22 | 56.24 ± 15.43 | 0.064 |
| Tumor size (cm) | ----- | 4.81 ± 3.11 | 4.71 ± 2.89 | 5.08 ± 3.65 | 0.023 |
| Survival time | ----- | 23.98 (10.03, 40.39) | 25.33 (9.81, 41.74) | 19.37 (10.61, 35.08) | <0.001 |
| Hospital | Taleghani | 1127 (60.17) | 889 (64.61) | 236 (47.97) | <0.001 |
| Sari | 219 (11.69) | 111 (8.07) | 108 (21.95) | ||
| Shiraz | 527 (28.14) | 376 (27.33) | 148 (30.08) | ||
| Sex | Male | 1112 (59.37) | 812 (59.01) | 297 (60.37) | 0.63 |
| Female | 761 (40.63) | 564 (40.99) | 195 (39.63) | ||
| Marital status | Married | 1777 (94.87) | 1315 (95.57) | 457 (92.89) | 0.024 |
| Other | 96 (5.13) | 61 (4.43) | 35 (7.11) | ||
| BMI – four categories | <18.5 | 140 (7.47) | 80 (5.81) | 58 (11.79) | <0.001 |
| 18.6-24.9 | 1024 (54.67) | 748 (54.36) | 274 (55.69) | ||
| 25-29.9 | 555 (29.63) | 421 (30.60) | 133 (27.03) | ||
| >30 | 154 (8.22) | 127 (9.23) | 27 (5.49) | ||
| BMI – three categories |
<18 | 145 (7.74) | 83 (6.03) | 60 (12.20) | <0.001 |
| 18-25 | 1019 (54.40) | 745 (54.14) | 272 (55.28) | ||
| >25 | 709 (37.85) | 548 (39.83) | 160 (32.52) | ||
| Smoking | No | 1340 (71.54) | 981 (71.29) | 354 (71.95) | 0.816 |
| Yes | 533 (28.46) | 395 (28.71) | 138 (28.05) | ||
| Education | Illiterate | 529 (28.24) | 380 (27.62) | 148 (30.08) | 0.286 |
| Primary school | 614 (32.78) | 459 (33.36) | 153 (31.10) | ||
| High school | 401 (21.41) | 305 (22.17) | 96 (19.51) | ||
| University | 329 (17.57) | 232 (16.86) | 95 (19.31) | ||
| Hypertension | No | 1666 (88.95) | 1216 (88.37) | 447 (90.85) | 0.153 |
| Yes | 207 (11.05) | 160 (11.63) | 45 (9.15) | ||
| Diabetes | No | 1684 (89.91) | 1232 (89.53) | 447 (90.85) | 0.434 |
| Yes | 189 (10.09) | 144 (10.47) | 45 (9.15) | ||
| Familial history of cancer | No | 1208 (64.50) | 865 (62.86) | 338 (68.70) | 0.021 |
| Yes | 665 (35.50) | 511 (37.14) | 154 (31.30) | ||
| Site topography | Right colon | 576 (30.75) | 421 (30.60) | 154 (31.30) | 0.02 |
| Left colon | 1094 (58.41) | 822 (59.74) | 268 (54.47) | ||
| Rectum | 183 (9.77) | 122 (8.87) | 61 (12.40) | ||
| Transverse | 20 (1.07) | 11 (0.80) | 9 (1.83) | ||
| Grade | Well differentiated | 1042 (55.63) | 819 (59.52) | 221 (44.92) | <0.001 |
| Moderately differentiated | 677 (36.15) | 470 (34.16) | 205 (41.67) | ||
| Poorly differentiated | 154 (8.22) | 87 (6.32) | 66 (13.41) | ||
| Pathologic primary tumor | T0 | 1074 (57.34) | 837 (60.83) | 232 (47.15) | <0.001 |
| T1 | 343 (18.31) | 214 (15.55) | 129 (26.22) | ||
| T2 | 143 (7.63) | 113 (8.21) | 30 (6.10) | ||
| T3 | 292 (15.59) | 202 (14.68) | 90 (18.29) | ||
| T4 | 21 (1.12) | 10 (0.73) | 11 (2.24) | ||
| Lymph node involved | N0 | 924 (49.33) | 731 (53.13) | 191 (38.82) | <0.001 |
| N1 | 798 (42.61) | 578 (42.01) | 217 (44.11) | ||
| N2 | 151 (8.06) | 67 (4.87) | 84 (17.07) | ||
| Metastasis | No | 1091 (58.25) | 857 (62.28) | 230 (46.75) | <0.001 |
| Yes | 284 (15.16) | 148 (10.76) | 136 (27.64) | ||
| Not known | 498 (26.59) | 371 (26.96) | 126 (25.61) | ||
| Stage | I | 281 (15.00) | 227 (16.50) | 52 (10.57) | <0.001 |
| II | 681 (36.36) | 526 (38.23) | 154 (31.30) | ||
| III | 631 (33.69) | 460 (33.43) | 169 (34.35) | ||
| IV | 280 (14.95) | 163 (11.85) | 117 (23.78) | ||
| Variable | Levels | Total (n=1873) | Vital status | P-value | |
| Survived or discharged (n=1396) | Deceased (n=492) | ||||
| First treatment | Surgery | 1336 (71.33) | 1051 (76.38) | 281 (57.11) | <0.001 |
| Chemotherapy & Radiation Therapy & Immunotherapy | 537 (28.67) | 325 (23.62) | 211 (42.89) | ||
| FAP | No | 1858 (99.20) | 1363 (99.06) | 490 (99.59) | 0.379 |
| Yes | 15 (0.80) | 13 (0.94) | 2 (0.41) | ||
| HNPCC | No | 1705 (91.03) | 1254 (91.13) | 446 (90.65) | 0.783 |
| Yes | 168 (8.97) | 122 (8.87) | 46 (9.35) | ||
| IBD | No | 1850 (98.77) | 1361 (98.91) | 484 (98.37) | 0.347 |
| Yes | 23 (1.23) | 15 (1.09) | 8 (1.63) | ||
| Personal history of CRC | No | 1764 (94.18) | 1296 (94.19) | 464 (94.31) | 1 |
| Yes | 109 (5.82) | 80 (5.81) | 28 (5.69) | ||
| Status | Survived or discharged | 1376 (73.47) | 1376 (100.00) | 0 (0.00) | ------ |
| Deceased | 492 (26.27) | 0 (0.00) | 492 (100.00) | ||
| NA | 5 (0.27) | 0 | 0 |
Note: Descriptive statistics were reported in terms of frequency (%) for categorical data. Symmetric and asymmetric numeric data were expressed as mean ± standard deviation (SD) and median (interquartile range [IQR]), respectively. The relationship between categorical variables and vital status was investigated using the Fisher exact test. Additionally, the differences in symmetric and asymmetric variables between the deceased and survived groups were assessed using the independent t-test and Mann-Whitney U test, respectively.