Figure 2.

AAV8 neutralizing IgM Ab titers and correlation with plasma BAFF levels

(A) Comparison of IgM and IgG2c Ab titers and IC₅₀ NAb dilution factors for representative samples from control (no-IS) and various IS treatment groups (n = 3–5/group) at 4 weeks. (B) Representative IC₅₀ dose-response curves showing percentage of transduction at various plasma dilutions. (C) Two-axis combined bar graph correlating circulating BAFF levels (left y axis) and IgM levels (right y axis) for naive, no-IS, and various IS groups. Significantly elevated BAFF levels are indicated. Statistical significance was calculated by 1-way ANOVA (Dunnett’s multiple comparisons) for (C). ∗p ≤ 0.05; ∗∗p ≤ 0.01; ∗∗∗p ≤ 0.001; ∗∗∗∗p ≤ 0.0001.