1.7. Analysis.

Comparison 1: Admission avoidance hospital at home versus inpatient care, Outcome 7: Functional status

Functional status
Study	Functional ability	Results
Admission avoidance patients with a medical condition ‐ functional ability
Caplan 1999	Change in Barthel score from admission to discharge (high score=greater independence) Instrumental activities of daily living score from admission to discharge (higher score=greater independence)	Mean (SEM) T= 0.37 (0.27), C= ‐0.04 (0.27), NS Mean (SEM) T= 0.65 (0.23), C= ‐0.88 (0.26), P = 0.037
Davies 2000	St Georges' respiratory questionnaire (to a random sub‐group of 90 participants). High score indicates poorer health related quality of life. A minimum change in score of 4 units is clinically relevant. Forced expiratory volume in one second (FEV1)	Baseline scores T= 71.5 (43.4 to 99.6), C= 71.0 (43.4 to 98.6) Mean (SD) change at 3 months T= 0.48 (16.92) C= 3.13 (14.02) Forced expiratory volume in 1 second (FEV1) At 3 months: T= 41.5% (95% CI 8.2% to 74.8%) C= 41.9% (95% CI 6.2% to 77.6%)
Levine 2018	Activities of daily living Instrumental activities of daily living	ADLs worse at discharge T = 9 (0%) C = 11 (9%) IADLs worse at discharge T = 9 (0%) C = 11 (18%)
Levine 2020	Instrumental activities of daily living Activities of daily living	IADLs worse: admission to discharge (%) T = 11 (26) N=42 C = 14 (31) N=45 IADLs worse: admission to 30d after discharge (%) T = 14 (37) N=42 C = 13 (34) N=38 ADLs worse: admission to discharge (%) T = 6 (14) N=42 C = 6 (13) N=45 ADLs worse: admission to 30d after discharge (%) T = 4 (11) N=42 C = 6 (16) N=38
Mendoza 2009	Activities of daily living	Mean score Barthel Index at 1 year (adjusted for baseline differences) T= 4.0 (‐0.9 to 8.9) C= 4.7 (‐2.2 to 11.5) P = 0.21
Ricauda 2008	Change in ADL (score 0 to 6)	At 6 months, mean (SD) T= 0.12 (0.64), C= 0.08 (0.73), P = 0.81
Shepperd 2021	Activities of daily living	Mean score Barthel Index at 6 months (SD) T = 15.8 (4.4) C = 15.6 (4.9) Adjusted mean difference (95% CI) 0.24 (‐0.33, 0.80) P=0.41
Tibaldi 2004	Behavioural disturbances	Sleeping disorders T= 5/56 (9%), C= 23/53 (43%), MD: ‐34%, 95% CI ‐50% to ‐19%, P < 0.001 Agitation/aggressiveness T= 5 /56 (9%), C= 22/53 (41.5%), MD ‐33% 95% CI ‐48% to ‐17%, P<0.001 Feeding disorders T= 5 /56 (9%), C= 21/53 (40%), MD ‐31% 95% CI ‐46% to ‐16%, P < 0.001
Tibaldi 2009	Activities of daily living Barthel Index	ADL at 6 months mean change T= ‐1.95 (9.61) N=48, C= ‐0.30 (10.12) N=53,
Wilson 1999	Barthel Index	Barthel Index At 3 months (Median (IQR)) T= 16 (13‐19), C= 16 (12‐20) Barthel Index ‐ number (%) not assessed: T= 21 (28%), C= 18 (28%) Sickness Impact Profile: At 3 months (Median (IQR)) T= 24 (20‐31), C= 26 (20‐31) Sickness Impact Profile ‐ no (%) not assessed T= 31 (41%), C= 30 (46%)