Quality of life/health status
Study	Outcomes	Results	Notes
Admission avoidance quality of life
Corwin 2005	SF 36 Physical functioning Role physical Pain	SF 36 Physical functioning Day 3 T= 37 (29.1), C= 41 (28.3) Mean difference ‐1.9, 95% CI ‐10.7 to 6.9 Day 6 T=50.7 (33.7), C=50.9 (31.6) Mean difference ‐5.2, 95% CI ‐13.7 to 3.2 Role physical Day 3 T= 5.4 (18.8), C=5.5 (19.7) Mean difference ‐1.8 95% CI ‐13.1 to 9.4 Day 6 T=21.1 (36.9), C=18.4 (36.5) Mean difference 2.2, 95% CI ‐10.7 to 15.1 Pain Day 3 T=57 (28.8), C=55.9 (25.4) Mean difference ‐2.5 95% CI ‐10.1 to 5.1 Day 6 T=69.8 (26.4), C=64.8 (25.6) Mean difference ‐3.8 95% CI ‐10.6 to 3.0	Differences calculated on absolute differences between day 0 & day 3, or day 0 & day 6. Numbers vary due to missing data (high score=better health)
Echevarria 2018	EQ‐5D‐5L utility 14 day EQ‐5D‐5L utility 90 day	EQ‐5D‐5L utility (SD), mean 14 day unit change from baseline T = 0.091 (0.249) C = 0.055 (0.316) EQ‐5D‐5L utility (SD), mean 90 day unit change from baseline T = 0.003 (0.287) C = 0.007 (0.338)
Mendoza 2009	SF 36 Physical component Mental component	Physical component T= 3.6 (‐0.5 to 7.7), C= 2.2 (‐1.9 to 6.4), P = 0.47 Mental component T= 4.0 (‐0.9 to 8.9), C= 2.8 (‐2.4 to 8.0), P = 0.38	Score at 1 year (adjusted for baseline differences)
Ricauda 2008	Nottingham Health Profile	6 months, mean (SD) T= 3.6 (7.9), C= 0.8 (4.5), P = 0.04	Changes at 6 months
Richards 2005	SF‐12 Mean physical and mental component score	Physical component At 2 weeks T= 38.1, C= 40.2, P = 0.45 At 6 weeks T= 42.2, C=45.8, P = 0.18 Mental component At 2 weeks T=48.3, C=48.6, P = 0.91 At 6 weeks T = 50.4, C=51.0, P = 0.81	higher score=better health
Shepperd 2021	Health status EQ‐5D‐5L utility Barthel Index	Mean EQ‐5D‐5L utility 6 months (SD) T = 0.451 (0.324) C = 0.457 (0.340) Difference in means (95% CI) ‐0.006 (‐0.053, 0.041) Mean (SD) Barthel Index at 6 months T = 15.8 (4.4) C = 15.6 (4.9) Adjusted mean difference (95% CI) 0.24 (‐0.33, 0.80) P=0.41
Talcott 2011	Quality of life EORTC QLQ C‐30	Role Function T= 0.58, C= 0.78, P = 0.05 Emotional Function T= 3.27, C= ‐6.94, P = 0.04	Quality of life data were collected at the time of consent to join the study, as soon as possible after the resolution of the episode. Data were collected for the first study episode. Change score
Tibaldi 2009	Nottingham Health Profile	6 months, mean (SD) T= +1.09 (2.57), C= +0.18 (1.94), P = 0.046
Wilson 1999	Sickness Impact Profile (SIP) Euroqol	SIP, median (IQR) T= 24 (20‐31), C= 26 (20‐31) Difference ‐2 (95% CI ‐4 to 4), P = 0.73 Euroqol, median T= 0.64, C= 0.63 Difference 0.01 (95% CI ‐0.12 to 0.09), P = 0.94	At 3 months follow‐up