Clinical outcomes
Study	Outcomes	Results
Clinical outcomes
Corwin 2005	No advancement of cellulitis (indelible line drawn around peripheral margin of the cellulitis and dated)	Mean (SD) days T= 1.5 (0.11), C= 1.49 (0.10), Mean difference 0.01 days, 95% CI ‐0.3 to 0.28 Days of no advancement of cellulites HR 0.98, 95% CI 0.73 to 1.32, P = 0.90 Days on intravenous antibiotics HR 0.84, 95% CI 0.63 to 1.12, P = 0.23 Days to discharge HR 0.93, 95% CI 0.70 to 1.23, P = 0.60 Days on oral antibiotics HR 1.09, 95% CI 0.82 to 1.45, P = 0.56
Davies 2000	Proportion of patients prescribed an antibiotic at 3 months	T= 56/100 (56%), C= 19/50 (38%), Difference 18%, 95% CI 1.4 to 34.6%
Echevarria 2018	COPD Assessment Tool (CAT) at 14 and 90 days	CAT, 14‐day (IQR) T = ‐4.0 (‐9.5, 0) C = ‐3.0 (‐7, 1) CAT, 90 day (IQR) T = ‐3.0 (‐8, 1) C = ‐1.0 (‐6, 1)
Levine 2020	Any safety event Median pain score Inappropriate medication use Urinary catheter use Restraint use	Any safety event (%) T = 4 (9) C = 7 (15) Median pain score (IQR) T = 0 (1) C = 0 (3) Inappropriate medication use T = 0 (0) C = 5 (10) Urinary catheter use T = 0 (0) C = 2 (4) Restraint use T = 0 (0) C = 0 (0)
Shepperd 2021	Charlson Comorbidity Index score	Mean at 6 months (SD) T = 6.17 (1.94) C = 6.00 (1.93) Adjusted mean difference (95% CI): 0.0002 (‐0.1452 to 0.1455)
Talcott 2011	Major medical complications during care in hospital at home or hospital	T= 4/47 (9%), C= 5/66 (8%), Difference 1%, 95% CI ‐10 to13%
Tibaldi 2004	Use of antipsychotic drugs	On admission T= 26/56 (46.4%), C= 18/56 (32%), Difference 14.3%, 95% CI ‐3.7% to 31.1% On discharge T= 6/56 (11%), C = 13/53 (25%), Difference 14%, 95% CI ‐28% to 0.3%