Table 1.
Patient clinicopathologic and metabolic characteristics in the whole cohort.
| Characteristics | Overall population n = 430 (%) |
|---|---|
| Age at ICI start | |
| Median (range) | 69.0 (32.0-92.0) |
| Sex | |
| Female | 142 (33.0%) |
| Male | 288 (67.0%) |
| Smoking status | |
| Current/former | 248 (57.0%) |
| Never | 169 (39%) |
| NA | 13 (4.0%) |
| Tumor type | |
| NSCLC | 266 (62.0%) |
| RCC | 74 (17.0%) |
| Melanoma | 55 (13.0%) |
| Others* | 35 (8.0%) |
| Treatment type | |
| ICI | 373 (87.0%) |
| ICI plus chemotherapy | 27 (6.0%) |
| ICI plus TKI | 30 (7.0%) |
| Treatment line | |
| First | 235 (55.0%) |
| ≥ second | 195 (45.0%) |
| ECOG PS | |
| 0-1 | 385 (89.0%) |
| ≥2 | 45 (10.0%) |
| Metastatic sites | |
| 0-1 | 103 (24.0%) |
| ≥2 | 327 (76.0%) |
| Diagnosis of DM | |
| No | 346 (81.0%) |
| Yes | 84 (19.0%) |
| CV disease | |
| No | 293 (68.0%) |
| Yes | 135 (31.0%) |
| NA | 2 (1.0%) |
| Hypertension | |
| No | 189 (44.0%) |
| Yes | 241 (56.0%) |
| Statin use | |
| No | 312 (72.0%) |
| Yes | 115 (27.0%) |
| NA | 3 (1.0%) |
| BMI | |
| Underweight (BMI < 18.5) |
18 (4.2%) |
| Normal (18.5 ≤ BMI ≤ 24.9) |
213 (49.5%) |
| Overweight (25 ≤ BMI ≤ 29.9) |
135 (31.4%) |
| Obese (BMI ≥ 30) |
60 (13.9%) |
| NA | 4 (0.9%) |
| TC | |
| <200 mg/dl | 295 (69.0%) |
| ≥200 mg/dl | 135 (31.0%) |
| HDL | |
| < 40 mg/dl (males) or < 50 mg/dl (females) | 92 (21.0%) |
| ≥ 40 mg/dl (males) or ≥ 50 mg/dl (females) | 167 (39.0%) |
| NA | 171 (40.0%) |
| LDL | |
| < 100 mg/dl | 150 (35.0%) |
| ≥ 100 mg/dl | 107 (25.0%) |
| NA | 173 (40.0%) |
| TG | |
| <150 mg/dl | 220 (52.0%) |
| ≥150 mg/dl | 96 (22.0%) |
| NA | 114 (26.0%) |
*Others: urothelial carcinoma, head and neck carcinoma, small cell lung cancer, and breast cancer
Abbreviations: HDL: high-density cholesterol; LDL: low-density cholesterol; ICI: immune checkpoint inhibitor; NSCLC: non-small cell lung cancer; RCC: renal cell carcinoma; TKI: tyrosine kinase inhibitor; ECOG PS: Eastern Cooperative Oncology Group-Performance Status; DM: diabetes mellitus; BMI: body mass index (kg/m2); NA: not available; TC: total cholesterol; TG: triglycerides.