Table 1.
Clinicopathological characteristics associated with HER2 status.
| Characteristics | Total | HER2-0 N(%) |
HER2-low N (%) |
Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|---|---|
| χ2 | P-value | OR | 95% CI | P-value | ||||
| Age at diagnosis | 42.953 | <.001 | ||||||
| ≤55 | 1077 | 611 (81.8) | 466 (66.8) | Reference | ||||
| >55 | 368 | 136 (18.2) | 232 (33.2) | 1.691 | 1.206-2.371 | .002 | ||
| Menopausal status | 27.688 | <.001 | ||||||
| Premenopausal | 831 | 479 (64.1) | 352 (50.4) | Reference | ||||
| Postmenopausal | 614 | 268 (35.9) | 346 (49.6) | 1.151 | 0.857-1.545 | .350 | ||
| Family history | 0.020 | .886 | ||||||
| No | 1410 | 729(97.6) | 681 (97.7) | |||||
| Yes | 34 | 18 (2.4) | 16 (2.3) | |||||
| T stage | 1.349 | .509 | ||||||
| T1 | 391 | 211 (28.2) | 180 (25.8) | |||||
| T2 | 951 | 486 (65.1) | 465 (66.6) | |||||
| T3 + T4 | 103 | 50 (6.7) | 53 (7.6) | |||||
| N stage | 5.121 | .077 | ||||||
| N0 | 789 | 428 (57.3) | 361 (51.7) | |||||
| N1 | 493 | 244 (32.7) | 249 (35.7) | |||||
| N2 + N3 | 163 | 75 (10.0) | 88 (12.6) | |||||
| Stage | 4.404 | .111 | ||||||
| I | 276 | 156 (20.9) | 120 (17.2) | |||||
| II | 969 | 497 (66.5) | 472 (67.6) | |||||
| III | 200 | 94 (12.6) | 106 (15.2) | |||||
| AR status | 91.374 | <.001 | ||||||
| <1% | 841 | 506(76.8) | 335 (51.5) | Reference | ||||
| ≥1% | 469 | 153 (23.2) | 316 (48.5) | 2.688 | 2.097-3.446 | <.001 | ||
| Ki-67 index | 27.785 | <.001 | ||||||
| ≤30% | 187 | 63 (8.4) | 124 (17.8) | Reference | ||||
| >30% | 1257 | 683 (91.6) | 574 (82.2) | 0.584 | 0.397-0.860 | .006 | ||
| Basal-like phenotype | 1.843 | .175 | ||||||
| No | 74 | 32 (4.6) | 42 (6.3) | |||||
| Yes | 1291 | 663 (95.4) | 628 (93.7) | |||||
| Histological type | 8.954 | .003 | ||||||
| Invasive ductal carcinoma | 1397 | 712 (95.3) | 685 (98.1) | Reference | ||||
| Other types* | 48 | 35 (4.7) | 13 (1.9) | 0.306 | 0.143-0.652 | .002 | ||
Other types* including invasive lobular carcinoma, metaplastic carcinoma, and carcinoma with medullary features.
Abbreviations: HER2: human epidermal growth factor receptor 2; AR: androgen receptor.