Table 2.
Clinicopathological characteristics associated with pCR.
| Characteristics | Total | non-pCR N (%) |
pCR N (%) |
Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|---|---|
| χ2 | P-value | OR | 95% CI | P-value | ||||
| Age at diagnosis | 1.118 | .290 | ||||||
| ≤55 | 430 | 270 (77.4) | 160 (81.2) | |||||
| >55 | 116 | 79 (22.6) | 37 (18.8) | |||||
| Menopausal status | 0.257 | .612 | ||||||
| Premenopausal | 336 | 212 (60.7) | 124 (62.9) | |||||
| Postmenopausal | 210 | 137 (39.3) | 73 (37.1) | |||||
| Family history | 0.001 | .977 | ||||||
| No | 532 | 340 (97.4) | 192 (97.5) | |||||
| Yes | 14 | 9 (2.6) | 5 (2.5) | |||||
| T stage | 7.963 | .019 | .028 | |||||
| T1 | 43 | 23 (6.6) | 20 (10.1) | Reference | ||||
| T2 | 409 | 255 (73.1) | 154 (78.2) | 0.558 | 0.271-1.152 | .115 | ||
| T3 + T4 | 94 | 71 (20.3) | 23 (11.7) | 0.317 | 0.134-0.752 | .009 | ||
| N stage | 19.589 | <.001 | .002 | |||||
| N0 | 143 | 79 (22.6) | 64 (32.5) | Reference | ||||
| N1 | 258 | 156 (44.7) | 102 (51.8) | 0.814 | 0.513-1.293 | .383 | ||
| N2 + N3 | 145 | 114 (32.7) | 31 (15.7) | 0.371 | 0.209-0.657 | .001 | ||
| AR status | 10.631 | .001 | ||||||
| <1% | 318 | 187(61.5) | 131 (76.2) | Reference | ||||
| ≥1% | 158 | 117 (38.5) | 41 (23.8) | 0.546 | 0.354-0.843 | .006 | ||
| Ki-67 index | 3.598 | .058 | ||||||
| ≤30% | 37 | 29 (8.3) | 8 (4.1) | Reference | ||||
| >30% | 509 | 320 (91.7) | 189 (95.9) | 2.135 | 0.834-5.464 | .114 | ||
| Basal-like phenotype | 0.007 | .933 | ||||||
| No | 22 | 14 (4.3) | 8 (4.5) | |||||
| Yes | 479 | 309 (95.7) | 170 (95.5) | |||||
| HER2 status | 0.359 | .549 | ||||||
| 0 | 254 | 159 (45.6) | 95 (48.2) | |||||
| Low | 292 | 190 (54.4) | 102 (51.8) | |||||
| HER2 status | 0.405 | .524 | ||||||
| 0/1+ | 405 | 262 (75.1) | 143 (72.6) | |||||
| 2+ and FISH- | 141 | 87 (24.9) | 54 (27.4) | |||||
| HER2 status | 1.699 | .428 | ||||||
| 0 | 254 | 159 (45.6) | 95 (48.2) | |||||
| 1+ | 151 | 103 (29.5) | 48 (24.4) | |||||
| 2+and FISH- | 141 | 87 (24.9) | 54 (27.4) | |||||
Abbreviations: pCR: pathological complete response; AR: androgen receptor; HER2: human epidermal growth factor receptor 2; IHC: immunohistochemistry; FISH: fluorescence in situ hybridization.