Table 3.
Univariate analysis of clinicopathological characteristics associated with BCSS and OS.
| Characteristics | BCSS | OS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age at diagnosis | .798 | .712 | ||||
| ≤55 | 1 | 1 | ||||
| >55 | 0.927 | 0.520-1.654 | 1.101 | 0.660-1.837 | ||
| Menopausal status | .315 | .704 | ||||
| Premenopausal | 1 | 1 | ||||
| Postmenopausal | 0.769 | 0.462-1.282 | 0.914 | 0.576-1.451 | ||
| Histological type | .395 | .304 | ||||
| Invasive ductal carcinoma | 1 | 1 | ||||
| Other types* | 0.424 | 0.059-3.060 | 0.355 | 0.049-2.557 | ||
| T stage | <.001 | <.001 | ||||
| T1 | 1 | 1 | ||||
| T2 | 2.988 | 1.272-7.021 | .012 | 2.557 | 1.211-5.398 | .014 |
| T3 + T4 | 9.833 | 3.778-25.591 | <.001 | 9.465 | 4.115-21.770 | <.001 |
| N stage | <.001 | <.001 | ||||
| N0 | 1 | 1 | ||||
| N1 | 2.784 | 1.285-6.032 | .009 | 2.321 | 1.180-4.564 | .015 |
| N2 + N3 | 18.756 | 9.286-37.886 | <.001 | 15.264 | 8.303-28.061 | <.001 |
| AR status | .231 | .108 | ||||
| <1% | 1 | 1 | ||||
| ≥1% | 1.376 | 0.816-2.322 | 1.487 | 0.917-2.411 | ||
| Ki-67 index | .958 | .598 | ||||
| ≤30% | 1 | 1 | ||||
| >30% | 1.020 | 0.486-2.140 | 1.218 | 0.585-2.535 | ||
| Basal-like phenotype | .825 | .622 | ||||
| No | 1 | 1 | ||||
| Yes | 1.140 | 0.357-3.638 | 1.338 | 0.421-4.252 | ||
| HER2 status | .030 | .152 | ||||
| 0 | 1 | 1 | ||||
| Low | 0.555 | 0.326-0.943 | 0.710 | 0.445-1.135 | ||
| HER2 status | .353 | .445 | ||||
| 0/1+ | 1 | 1 | ||||
| 2 + and FISH- | 0.734 | 0.383-1.408 | 0.797 | 0.446-1.426 | ||
| HER2 status | .086 | .357 | ||||
| 0 | 1 | 1 | ||||
| 1+ | 0.490 | 0.239-1.005 | .052 | 0.696 | 0.383-1.265 | .235 |
| 2 + and FISH- | 0.622 | 0.320-1.207 | .160 | 0.725 | 0.399-1.317 | .291 |
| Type of surgery | .002 | .003 | ||||
| Breast-conserving | 1 | 1 | ||||
| Mastectomy | 3.732 | 1.605-8.636 | 2.869 | 1.430-5.758 | ||
| Radiation therapy | <.001 | <.001 | ||||
| No | 1 | 1 | ||||
| Yes | 3.349 | 1.748-6.419 | 3.091 | 1.729-5.526 | ||
Other types* including invasive lobular carcinoma, metaplastic carcinoma, and carcinoma with medullary features.
Abbreviations: BCSS: breast cancer-specific survival; OS: overall survival; AR: androgen receptor; HER2: human epidermal growth factor receptor 2; IHC: immunohistochemistry; FISH: fluorescence in situ hybridization.