Table 3.
Association Between Anion Gap (AG) and All-Cause Mortality Risk in Different Models
| Variable | N.total | N.event_% | Crude Model | Model-I | Model-II | |||
|---|---|---|---|---|---|---|---|---|
| OR (95CIs) | P value | OR (95CIs) | P value | OR (95CIs) | P value | |||
| AG(mmol/L) | 5531 | 760 (13.7) | 1.13 (1.11~1.15) | <0.001 | 1.09 (1.07~1.11) | <0.001 | 1.06 (1.04~1.09) | <0.001 |
| AG group(mmol/L) | ||||||||
| Q1 (≤11) | 1279 | 104 (8.1) | 1 (Ref) | 1 (Ref) | 1 (Ref) | |||
| Q2 (12–13) | 1255 | 119 (9.5) | 1.18 (0.9~1.56) | 0.231 | 0.96 (0.69~1.34) | 0.82 | 0.89 (0.63~1.25) | 0.502 |
| Q3 (14–15) | 1133 | 138 (12.2) | 1.57 (1.2~2.05) | 0.001 | 1.13 (0.82~1.56) | 0.448 | 0.95 (0.68~1.34) | 0.788 |
| Q4 (≥16) | 1864 | 399 (21.4) | 3.08 (2.45~3.87) | <0.001 | 2.05 (1.56~2.68) | <0.001 | 1.49 (1.1~2.02) | 0.009 |
| P for trend | <0.001 | <0.001 | 0.001 | |||||
Notes: Crude model adjusted for: none. Model-I adjusted for: age, gender, race and vital signs (heart rate, respiratory rate, mean blood pressure, temperature). Model II adjusted for: age, gender, race, vital signs(heart rate, respiratory rate, mean blood pressure, temperature), comorbidity (congestive heart failure, cerebrovascular disease, peptic ulcer, renal disease malignancy and sepsis), platelet, BUN, WBC, creatinine, hematocrit, hemoglobin, glucose, and Charlson Comorbidity Index.
Abbreviations: AG, anion gap; Q, quartile; OR, odds ratio; CI, confidence interval; Ref, reference.