Table 3.
Top 10 SNPs by adjusted p-value.
| Rank | rsID | Chromosome | Gene | Allele | MAF | Adjusted HR (95% CI) | Adjusted P-value |
|---|---|---|---|---|---|---|---|
| 1 | rs1478947 | 8 | NA | G > A | 0.06 | 6.26 (3.19–12.28) | 9.40 × 10−8 |
| 2 | rs8064614 | 17 | AATF | G > A | 0.20 | 3.60 (2.18–5.95) | 5.83 × 10−7 |
| 3 | rs10513906 | 18 | NA | G > A | 0.26 | 3.67 (2.17–6.21) | 1.23 × 10−6 |
| 4 | rs12546435a | 8 | SNTG1 | G > A | 0.14 | 3.19 (1.96–5.19) | 3.26 × 10−6 |
| 5 | rs10993698 | 9 | SYK | C > A | 0.13 | 3.61 (2.05–6.35) | 8.83 × 10−6 |
| 6 | rs203898a | 8 | SNTG1 | C > A | 0.13 | 3.03 (1.86–4.95) | 9.36 × 10−6 |
| 7 | rs203927a | 8 | SNTG1 | G > A | 0.13 | 3.03 (1.86–4.95) | 9.36 × 10−6 |
| 8 | rs203959a | 8 | SNTG1 | G > A | 0.14 | 3.03 (1.85–4.95) | 9.84 × 10−6 |
| 9 | rs203946a | 8 | SNTG1 | G > A | 0.14 | 3.02 (1.85–4.94) | 1.01 × 10−5 |
| 10 | rs11870749 | 17 | AATF | A > G | 0.22 | 3.04 (1.84–5.01) | 1.40 × 10−5 |
SNP single nucleotide polymorphism, HR cause-specific hazard ratio, MAF minor allele frequency, NA not applicable, meaning the SNP was not found within a gene (i.e., intergenic).
ars12546435, rs203898, rs203927, rs203959, rs203946 are all in high linkage disequilibrium (LD) (r2 ≥ 0.90), none of which are in LD with the top SNP rs1478947.