Table 2.
Univariate Cox proportional hazards analysis.
| Subgroup | Univariate analysis HR (95%CI) |
P-value |
|---|---|---|
| Sequence number | ||
| Single primary | Reference (1) | |
| 1st of two or more primaries | 0.40 (0.39, 0.42) | <0.01 |
| 2nd of two or more primaries | 0.86 (0.84, 0.87) | <0.01 |
| Sex | ||
| Male | Reference (1) | |
| Female | 0.87 (0.86, 0.89) | <0.01 |
| Age | ||
| < 75 years | Reference (1) | |
| ≥ 75 years | 1.33 (1.31, 1.35) | <0.01 |
| Race | ||
| White | Reference (1) | |
| Black | 1.08 (1.05, 1.10) | <0.01 |
| Others(a) | 1.00 (0.98, 1.03) | 0.92 |
| Grade | ||
| Grade 1(b) | Reference (1) | |
| Grade 2(c) | 1.14 (1.12, 1.16) | <0.01 |
| Unknown | 1.49 (1.46, 1.51) | <0.01 |
| Primary site | ||
| Main bronchus | Reference (1) | |
| Lung lobe | 0.67 (0.65, 0.69) | <0.01 |
| Others(d) | 1.11 (1.08, 1.15) | <0.01 |
| Historic stage | ||
| Localized | Reference (1) | |
| Regional | 1.51 (1.48, 1.54) | <0.01 |
| Distant | 3.34 (3.26, 3.41) | <0.01 |
| Unknown | 1.85 (1.81, 1.88) | <0.01 |
| Regional nodes | ||
| Not examined | Reference (1) | |
| Negative | 0.38 (0.37, 0.39) | <0.01 |
| Positive | 0.65 (0.64, 0.66) | <0.01 |
| Laterality | ||
| Right | Reference (1) | |
| Left | 0.95 (0.94, 0.97) | <0.01 |
| Others(e) | 1.78 (1.72, 1.85) | <0.01 |
| Marital status | ||
| Partnered(f) | Reference (1) | |
| Alone(g) | 1.13 (1.11, 1.14) | <0.01 |
| Unknown | 1.10 (1.06, 1.14) | <0.01 |
| Radiation | ||
| Yes | Reference (1) | |
| No | 1.37 (1.29, 1.46) | <0.01 |
| Unknown | 0.74 (0.73, 0.75) | <0.01 |
| Surgery | ||
| Yes | Reference (1) | |
| No | 3.05 (3.00, 3.10) | <0.01 |
| Unknown | 3.42 (3.31, 3.53) | <0.01 |
| Chemotherapy | ||
| Yes | Reference (1) | |
| No | 1.06 (1.05, 1.08) | <0.01 |
| Year of diagnosis | ||
| 1975–1989 | Reference (1) | |
| 1990–2004 | 0.93 (0.92, 0.95) | <0.01 |
| 2005–2019 | 0.79 (0.78, 0.81) | <0.01 |
| Months between diagnosis and treatment | ||
| < 1 month | Reference (1) | |
| 1 month | 0.97 (0.96, 0.99) | <0.01 |
| > 2 months | 0.79 (0.78, 0.81) | <0.01 |
| Unknown | 2.31 (2.27, 2.35) | <0.01 |
(a) American Indian/AK Native, Asian/Pacific Islander. (b) Well- and moderately-differentiated cancers. (c) Poorly-differentiated, undifferentiated, and anaplastic cancers. (d) Other primary sites included C34.8 (overlapping lung lesions) and C34.9 (lung, not otherwise specified). (e) Bilateral single primaries and unpaired sites, single unspecified side, and paired sites without information about laterality. (f) Married individuals and those with a domestic partner. (g) Divorced, separated, single (never married), and widowed individuals.