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. 2024 Mar 4;10(1):17. doi: 10.1038/s41514-024-00144-6

Fig. 1. Changes in APC frequencies and phenotypes with age.

Fig. 1

Shown in a are t-distributed stochastic neighbor embedding (t-SNE) plots of HOC (n = 15) and HYC (n = 15), including a plot indicating the localization of clusters with classical monocytes (CD14+CD16-), intermediate monocytes (CD16+CD14+), non-classical monocytes (CD14lowCD16+), conventional dendritic cells (CD141/CD1c+) and plasmacytoid dendritic cells (CD303+). In b, we show the proportion within total PBMCs of the APC subsets between the HOC and HYC groups. The red line indicates the median and the p-values of Mann–Whitney U testing are indicated in the graph. Additionally, we show the MFI for eight markers for each subset, for the HOC and HYC groups. These data are expressed as median ± inter-quartile range, and statistical differences (P < 0.05) in expression between the groups, by Mann–Whitney U, are indicated with ‘*’. APC antigen-presenting cell, HOC healthy control, HYC healthy young control, PBMC peripheral blood mononuclear cells, MFI mean fluorescence intensity.