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. 2024 Mar 4;15:1982. doi: 10.1038/s41467-024-45805-y

Fig. 9. Treatment with an inhibitor of CTPS1 reduces EAE symptoms.

Fig. 9

a–d EAE was induced by the immunisation of 12-wk-old C57BL/6 mice with MOG peptide. a Clinical score for Stp-2-drug (green) and vehicle (black) treated animals. b Representative traces of locomotor activity recorded in an open field cage for 10 min in control mice with no EAE and EAE-induced mouse treated with vehicle (Vt) and in Stp-2 compound (Dt) treated mouse. Quantification of the total distances travelled for 10 min. c, d Assessment of cellular infiltration by staining with haematoxylin/eosin and luxol blue counterstained with cresyl violet. Representative haematoxylin-eosin staining (c) and Luxol fast blue/cresyl violet counter-staining (d) of spinal cord sections of non-EAE and EAE-induced mouse treated with vehicle (Vt) and in Stp-2 compound (Dt) treated mouse. Images are representatives of four animals per group. (Scale bars 500 µm and 100 µm). Two-way ANOVA. Data are presented as mean ± SEM of n = 10 (vehicle-treated) and n = 13 (drug-treated) animals per group (a). One way ANOVA with Tukey’s multiple comparisons test n = 3 animals per group. Source data are provided in Source Data file.