Table 2.
Percent sensitivity of serum biomarkers for benign disease and for early stage (I-II) and late stage (III-IV) ovarian cancer at 98% specificity in healthy controls evaluated in the EDRN validation serum set.
| Ag/AAb | Biomarker/Sensitivity (%) | Benign | Early | Late | All cases |
|---|---|---|---|---|---|
| TP53 (RAPID) | 0.5 | 12.5 | 25.3 | 22.0 | |
| IL-8 | 8.5 | 26.5 | 15.6 | 18.4 | |
| CTAG1 | 3.0 | 7.9 | 19.4 | 16.4 | |
| AAb | |||||
| HE4 Ag-AAb | 3.0 | 18.8 | 8.6 | 11.2 | |
| CA125 | 22.0 | 62.5 | 93.5 | 85.6 | |
| HE4 | 0.0 | 40.6 | 86.0 | 74.4 | |
| Ag | OPN | 4.0 | 12.5 | 22.6 | 20.0 |
| HK 6 | 1.0 | 6.3 | 46.7 | 36.3 | |
| HK10 | 2.0 | 9.4 | 49.5 | 39.2 | |