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. 2024 Mar 4;14:5305. doi: 10.1038/s41598-024-55296-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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TIGIT is expressed on T-cells and Natural Killer cells in GBM. Histological (A) and scRNAseq (B,C) analyses and assessment of TIGIT expression in murine and patient derived GBM tissues. (A) IHC staining of CD3 (left) and TIGIT (right) expression on murine GL261 tissue extracted from 2-week tumor mice. (B) Violin plots visualizing TIGIT expression in all glioma cell types among patients with low-grade glioma (LGG), newly diagnosed high-grade glioma (ndGBM), and recurrent high-grade glioma (rGBM); ** denotes p value ≤ 0.01, *** ≤ 0.001 (C). Color-coded clustered UMAPs visualizing TIGIT expression in all patient GBM cell types.