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. 2024 Mar 4;14:5365. doi: 10.1038/s41598-024-55320-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Humoral response. Neutralizing antibody (NAb) titers were measured by ancestral strain derived vesicular stomatitis virus pseudovirus neutralization assay in (A) the Evaluable Immunogenicity Population (EIP), (B) the EIP with NAb titers ≤ 30 NT50 at baseline and C) the modified Intent-to-Treat population (mITT). (D) Anti-Spike IgG were measured by ELISA in the mITT population. Geometric mean titers (GMT) including values at the top of the corresponding histograms ± 95% Confidence Interval (CI) represented. The covariance analysis (SAS) of comparing GMT at Day 35/42 in the EIP participants (primary immunological endpoint) are summarized at the top of the corresponding time point histograms (A, B). † Indicates statistically significant (p ≤ 0.0001, paired t-test on log-transformed values, SAS) differences from all other treatment-matched time points. The p values for all the other comparisons are presented within group across timepoints (C, D).