Table 2.
Summary of significantly changing uEV proteins previously identified as GBM-EV biomarkers in other biofluids (ex vivo CUSA or neurosurgical aspirates, peripheral plasma and GBM culture media).
| Uniprot ID | Gene Name | Protein Name | GBM uEV Diagnostic | GBM uEV Burden | GBM uEV Recurrence | GBM uEV Resistance | Significant GBM-EV finding in other biofluid | REF |
|---|---|---|---|---|---|---|---|---|
| P31949 | S100A11 | Protein S100-A11 | X | X | X | CUSA-EV | [3] | |
| P07602 | PSAP | Prosaposin | X | X | X | PLASMA-EV + in vitro marker | [5, 40] | |
| Q14764 | MVP | Major vault protein | X | X | in vitro marker | [40] | ||
| Q9NZM1 | MYOF | Myoferlin | X | X | CUSA-EV | [3] | ||
| Q01469 | FABP5 | Fatty acid-binding protein 5 | X | X | CUSA-EV | [3] | ||
| Q92820 | GGH | Gamma-glutamyl hydrolase | X | X | in vitro EV marker | [40] | ||
| P21796 | VDAC1 | Voltage-dependent anion-selective channel protein 1 | X | X | CUSA-EV | [3] | ||
| P04075 | ALDOA | Fructose-bisphosphate aldolase A | X | X | in vitro EV marker | [40] | ||
| P10619 | CTSA | Lysosomal protective protein | X | X | in vitro EV marker | [40] | ||
| P10909 | CLU | Clusterin | X | X | in vitro EV marker | [40] | ||
| P01023 | A2M | Alpha-2-macroglobulin | X | X | in vitro EV marker | [40] | ||
| P04080 | CSTB | Cystatin-B | X | CUSA-EV | [3] | |||
| Q5VW32 | BROX | BRO1 domain-containing protein BROX | X | PLASMA-EV | [5] | |||
| P13987 | CD59 | CD59 glycoprotein | X | CUSA-EV | [3] | |||
| P25786 | PSMA1 | Proteasome subunit alpha type 1 | X | in vitro EV marker | [40] | |||
| Q9UN37 | VPS4A | Vacuolar protein sorting-associated protein 4A | X | PLASMA-EV | [5] | |||
| Q13200 | PSMD2 | 26 S proteasome non-ATPase regulatory subunit 2 | X | CUSA EV + in vitro marker | [3, 40] | |||
| O00231 | PSMD11 | 26 S proteasome non-ATPase regulatory subunit 11 | X | in vitro EV marker | [40] | |||
| P35579 | MYH9 | Myosin-9 | X | in vitro EV marker | [40] | |||
| P46781 | RPS9 | 40 S ribosomal protein S9 | X | CUSA EV + In vitro marker | [3, 40] | |||
| P22695 | UQCRC2 | Cytochrome b-c1 complex subunit 2, mitochondrial | X | CUSA-EV | [3] | |||
| Q5JWF2 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | X | CUSA-EV | [3] | |||
| P07355 | ANXA2 | Annexin A2 | X | CUSA-EV | [3] | |||
| P04083 | ANXA1 | Annexin A1 | X | CUSA EV + In vitro marker | [3, 40] | |||
| O43242 | PSMD3 | 26 S proteasome non-ATPase regulatory subunit 3 | X | in vitro EV marker | [40] | |||
| P49368 | CCT3 | T-complex protein 1 subunit gamma | X | CUSA EV + In vitro marker | [3, 40] | |||
| P55072 | VCP | Transitional endoplasmic reticulum ATPase | X | in vitro GBM EV marker | [40] | |||
| Q16851 | UGP2 | UTP--glucose-1-phosphate uridylyltransferase | X | CUSA EV + In vitro marker | [3, 40] | |||
| P53396 | ACLY | ATP-citrate synthase | X | in vitro EV marker | [40] | |||
| P52907 | CAPZA1 | F-actin-capping protein subunit alpha-1 | X | CUSA-EV | [3] | |||
| Q99832 | CCT7 | T-complex protein 1 subunit eta | X | PLASMA-EV + CUSA EV | [3, 5] | |||
| P49327 | FASN | Fatty acid synthase | X | in vitro EV marker | [40] | |||
| O75882 | ATRN | Attractin | X | in vitro EV marker | [40] | |||
| P59666 | DEFA3 | Neutrophil defensin 3 | X | CUSA-EV | [3] | |||
| P55060 | CSE1L | Exportin-2 | X | PLASMA-EV | [4] | |||
| Q14974 | KPNB1 | Importin subunit beta 1 | X | in vitro EV marker | [40] | |||
| P17987 | TCP1 | T-complex protein 1 subunit alpha | X | CUSA EV + In vitro marker | [3, 40] | |||
| Q86VP6 | CAND1 | Cullin-associated NEDD8-dissociated protein 1 | X | in vitro EV marker | [40] | |||
| P01008 | SERPINC1 | Antithrombin-III | X | in vitro EV marker | [40] | |||
| P40227 | CCT6A | T-complex protein 1 subunit zeta | X | CUSA-EV | [3] | |||
| P28838 | LAP3 | Cytosol aminopeptidase | X | CUSA-EV | [3] | |||
| P60174 | TPI1 | Triosephosphate isomerase | X | in vitro EV marker | [40] | |||
| Q92542 | NCSTN | Nicastrin | X | CUSA-EV | [3] | |||
| P50991 | CCT4 | T-complex protein 1 subunit delta | X | in vitro EV marker | [40] | |||
| O15498 | YKT6 | Synaptobrevin homolog YKT6 | X | PLASMA-EV | [5] | |||
| O60884 | DNAJA2 | DnaJ homolog subfamily A member 2 | X | CUSA-EV | [3] | |||
| P01011 | SERPINA3 | Alpha-1-antichymotrypsin | X | CUSA-EV | [3] | |||
| P25705 | ATP5F1A | ATP synthase subunit alpha, mitochondrial | X | CUSA-EV | [3] | |||
| Q9UBI6 | GNG12 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 | X | CUSA-EV | [3] | |||
| P08238 | HSP90AB1 | Heat shock protein HSP 90-beta | X | CUSA EV + In vitro marker | [3, 40] | |||
| P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | X | CUSA EV + In vitro marker | [3, 40] | |||
| P62258 | YWHAE | 14-3-3 protein epsilon | X | in vitro EV marker | [40] | |||
| O00299 | CLIC1 | Chloride intracellular channel protein 1 | X | CUSA-EV | [3] | |||
| P45880 | VDAC2 | Voltage-dependent anion-selective channel protein 2 | X | CUSA-EV | [3] | |||
| P05362 | ICAM1 | Intercellular adhesion molecule 1 (ICAM-1) | X | CUSA-EV | [3] | |||
| P06727 | APOA4 | Apolipoprotein A-IV | X | CUSA-EV | [3] | |||
| P05556 | ITGB1 | Integrin beta 1 | X | PLASMA-EV + in vitro marker | [5, 40] | |||
| P07339 | CTSD | Cathepsin D | X | in vitro EV marker | [40] | |||
| Q9NT62 | ATG3 | Ubiquitin-like-conjugating enzyme ATG3 | X | CUSA-EV | [3] | |||
| P01009 | SERPINA1 | Alpha-1-antitrypsin | X | CUSA-EV | [3] | |||
| O75369 | FLNB | Filamin-B | X | in vitro EV marker | [40] | |||
| P28074 | PSMB5 | Proteasome subunit beta type 5 | X | in vitro EV marker | [40] | |||
| Q99497 | PARK7 | Parkinson disease protein 7 | X | PLASMA-EV | [5] | |||
| P20618 | PSMB1 | Proteasome subunit beta type 1 | X | in vitro EV marker | [40] |