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IC50 values for naloxone when challenged with EC90 values of DAMGO, fentanyl, and acrylfentanyl.
| Drug | IC50 (nM) | 95% CI (nM) | Relative naloxone requirement (× fentanyl) | p-Value |
|---|---|---|---|---|
| DAMGO | 10.8 | 8.40–14.0 | 1.9 | 0.9766 |
| Fentanyl | 5.64 | 4.29–7.41 | 1.0 | NA |
| Carfentanil* | 61.4 | 33.9–110.3 | 10.9 | 0.0002 |
| Acrylfentanyl | 11.8 | 9.26–15.0 | 2.09 | 0.9623 |
DAMGO, [d-Ala2,NMe-Phe4,Gly-ol5]-enkephalin.
*Statistical significance by one-way ANOVA when compared to the naloxone IC50 against fentanyl.
NA = Not applicable.
