Table 5.
Univariate and multivariate analyses of factors associated with disease-free survival#.
| Factors | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Low CXI | Low H-CXI | |||||
| HR (95%CI) | p | HR (95%CI) | p | HR (95%CI) | p | |
| Age, years | ||||||
| ≥75/<75 | 1.933 (1.606–2.327) | <0.001 * | 1.756 (1.437–2.145) | <0.001 * | 1.710 (1.398–2.092) | <0.001 * |
| Sex | ||||||
| Male/Female | 0.906 (0.760–1.081) | 0.275 | 0.942 (0.788–1.126) | 0.511 | 0.939 (0.786–1.122) | 0.489 |
| BMI, kg/m2 | ||||||
| ≥25/<25 | 0.917 (0.744–1.130) | 0.417 | – | – | – | – |
| Low CXI | ||||||
| Yes/No | 1.705 (1.419–2.050) | <0.001 * | 1.611 (1.334–1.946) | <0.001 * | ||
| Low H-CXI | ||||||
| Yes/No | 1.838 (1.532–2.205) | <0.001 * | – | – | 1.642 (1.357–1.986) | <0.001 * |
| Cachexia | ||||||
| Yes/No | 1.277 (1.060–1.539) | 0.010 * | 1.114 (0.891–1.392) | 0.345 | 1.148 (0.920–1.431) | 0.222 |
| Anemia | ||||||
| Yes/No | 1.166 (0.974–1.394) | 0.094 | 0.901 (0.745–1.089) | 0.280 | 0.876 (0.723–1.062) | 0.179 |
| NRS2002 | ||||||
| ≥3/<3 | 1.227 (1.024–1.471) | 0.026 * | 0.980 (0.787–1.220) | 0.855 | 0.967 (0.778–1.201) | 0.759 |
| ASA grade | ||||||
| III/I, II | 1.478 (1.144–1.908) | 0.003 * | 1.376 (1.056–1.792) | 0.018 * | 1.269 (0.975–1.651) | 0.076 |
| Previous abdominal surgery | ||||||
| Yes/No | 1.132 (0.914–1.401) | 0.257 | – | – | – | – |
| Tumor location | ||||||
| Rectum/Colon | 0.958 (0.802–1.145) | 0.640 | – | – | – | – |
| Differentiation of tumor | ||||||
| Low/median or high | 1.529 (1.222–1.913) | <0.001 * | 1.417 (1.124–1.785) | 0.003 * | 1.377 (1.093–1.735) | 0.007 * |
| TNM stage | ||||||
| II/<I | 1.223 (0.960–1.557) | 0.103 | 1.142 (0.894–1.458) | 0.287 | 1.151 (0.902–1.470) | 0.258 |
| III/<I | 1.772 (1.397–2.248) | <0.001 * | 1.630 (1.277–2.082) | <0.001 * | 1.646 (1.290–2.101) | <0.001 * |
| Combined organ resection | ||||||
| Yes/No | 1.076 (0.756–1.531) | 0.684 | – | – | – | – |
| Laparoscopic surgery | ||||||
| Yes/No | 0.839 (0.705–0.999) | 0.049 * | 0.938 (0.784–1.121) | 0.480 | 0.951 (0.796–1.138) | 0.584 |
HR, hazard ratio; CI, confidence interval; BMI, body mass index; CXI, cachexia index; NRS2002, Nutritional Risk Screening 2002; ASA, American Society of Anesthesiologists; TNM, tumor-node-metastasis. * Statistically significant. # Cox proportional hazards models were utilized.