Table 6.
Univariate and multivariate analyses of factors associated with cancer cachexia.
| Factors | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Low CXI | Low H-CXI | |||||
| OR (95%CI) | p | OR (95%CI) | p | OR (95%CI) | p | |
| Age, years | ||||||
| ≥75/<75 | 1.572 (1.197–2.064) | 0.001 * | 0.753 (0.534–1.061) | 0.105 | 0.795 (0.564–1.122) | 0.192 |
| Sex | ||||||
| Male/Female | 0.815 (0.639–1.040) | 0.100 | 0.900 (0.674–1.201) | 0.474 | 0.896 (0.672–1.195) | 0.454 |
| BMI, kg/m2 | ||||||
| ≥25/<25 | 0.396 (0.282–0.555) | < 0.001 * | 0.529 (0.360–0.775) | 0.001 * | 0.509 (0.347–0.746) | 0.001 * |
| Low CXI | ||||||
| Yes/No | 1.595 (1.224–2.078) | 0.001 * | 1.448 (1.049–1.998) | 0.024 * | – | – |
| Low H-CXI | ||||||
| Yes/No | 1.326 (1.014–1.734) | 0.039 * | – | – | 1.012 (0.729–1.405) | 0.944 |
| Anemia | ||||||
| Yes/No | 1.891 (1.479–2.416) | < 0.001 * | 1.439 (1.066–1.942) | 0.017 * | 1.481 (1.098–1.999) | 0.010 * |
| NRS2002 | ||||||
| ≥3/<3 | 11.476 (8.699–15.139) | < 0.001 * | 11.394 (8.487–15.297) | < 0.001 * | 11.287 (8.416–15.137) | < 0.001 * |
| ASA grade | ||||||
| III/I, II | 1.052 (0.720–1.536) | 0.793 | – | – | – | – |
| Previous abdominal surgery | ||||||
| Yes/No | 1.201 (0.894–1.613) | 0.224 | – | – | – | – |
| Tumor location | ||||||
| Rectum/Colon | 0.760 (0.592–0.976) | 0.032 * | 1.045 (0.774–1.411) | 0.775 | 1.054 (0.780–1.422) | 0.733 |
| Differentiation of tumor | ||||||
| Low/median or high | 1.305 (0.942–1.806) | 0.109 | – | – | – | – |
| TNM stage | ||||||
| II/<I | 1.681 (1.202–2.351) | 0.002 * | 1.467 (0.994–2.166) | 0.054 | 1.468 (0.955–2.164) | 0.053 |
| III/<I | 2.230 (1.592–3.123) | < 0.001 * | 2.120 (1.430–3.142) | < 0.001 * | 2.131 (1.439–3.154) | < 0.001 * |
OR, odds ratio; CI, confidence interval; BMI, body mass index; CXI, cachexia index; NRS2002, Nutritional Risk Screening 2002; ASA, American Society of Anesthesiologists; TNM, tumor-node-metastasis. * Statistically significant.