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. 2024 Feb 20;15:1354297. doi: 10.3389/fimmu.2024.1354297

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Copyright © 2024 Masad, Idriss, Mohamed, Al-Sbiei, Bashir, Al-Marzooq, Altahrawi, Fernandez-Cabezudo and Al-Ramadi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microbiota variations after 4-week treatment. LDA analysis comparing genera pre and post-treatment with CS (A) and MH (B) showed depleted (red) and enriched (blue) in week 4 post-treatment. Venn diagram (C) of shared and unique genera that were significantly different pre- and post-treatment for each of the SC and MH groups. The heatmap (D) shows microbiota fingerprints in each group before and after treatment, with significantly altered genera. Asterisks (*) represent genera with significant differences between MH and CS after 4 weeks of treatment, while the rest are those with significant difference in week 0 compared to week 4 in either treatment group.