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. 2024 Mar 4;15:1977. doi: 10.1038/s41467-024-46085-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Browser track depicting per CpG mCG levels for PMDs (PMD partially methylated domain, dark blue) on scaffold PIZI01000031v1. All lamprey mCG values in this figure are from merged WGBS replicates. B Cluster heatmap of Spearman correlation of genomic PMD overlap. C Percentage of genome impacted by changes in PMD state in pairwise comparisons of samples (E egg, S sperm, 1 day 1, 2 day 2). D Browser track depicting mCG profiles of reprogrammed PMDs. E Schematic depicting major PMD reprogramming dynamics and the percentage of the genome associated with reprogramming events. UMR - unmethylated region, LMR - lowly methylated region, HyperMR- hypermethylated region. F Proportion of discordant reads (PDR) and mCG levels at reprogrammed PMDs. PDR and mCG levels are calculated from merged WGBS replicates for each tissue.