Table 3.
Hazard ratio (95% confidence intervals) of clinical outcome for adjuvant chemotherapy stratified by short-term state chain.
| State chain | Event | N | Overall Survival | P value * | |
|---|---|---|---|---|---|
| Unadjusted | Adjusted with PS score# | <0.0001 | |||
| Low-Low | 339 | 856 | 1.09 (0.74, 1.61) | 0.80 (0.54, 1.19) | |
| High-Low | 111 | 214 | 1.34 (0.59, 3.05) | 1.06 (0.46, 2.47) | |
| Low-High | 102 | 157 | 0.38 (0.20, 0.72) | 0.29 (0.15, 0.57) | |
| High-High | 78 | 95 | 0.41 (0.21, 0.79) | 0.38 (0.20, 0.73) | |
| State chain | Event | N | Disease-free Survival | P value | |
| Unadjusted | Adjusted with PS score# | <0.0001 | |||
| Low-Low | 355 | 856 | 1.09 (0.75, 1.58) | 0.83 (0.57, 1.21) | |
| High-Low | 116 | 214 | 1.00 (0.49, 2.06) | 0.74 (0.35, 1.57) | |
| Low-High | 106 | 157 | 0.44 (0.23, 0.82) | 0.34 (0.17, 0.67) | |
| High-High | 78 | 95 | 0.51 (0.26, 0.97) | 0.47 (0.24, 0.91) | |
# PS score was calculated by age, sex, TNM stage, location, differential, lymphovascular invasion, and nerve invasion.
* All P values for interaction < 0.0001 before or after adjustment with PS score.
Low/High: Low risk or high risk at baseline or 1 month after surgery.