TABLE 2.

Targeting one-carbon metabolic enzymes in tumors.

Gene	Methods	Cancer type	Results	Status	Reference
MTHFD2	Inhibitor	Colorectal cancer	Inhibiting growth, lung and peritoneal metastasis	Preclinical	Ju et al. (2019)
	LY345899
	Inhibitor TH9619	Acute myeloid leukemia	Inhibiting growth	Preclinical	Bonagas et al. (2022)
	Inhibitor DS18561882	Prostate cancer	Inhibiting growth	Preclinical	Zhao et al. (2022)
	siRNA	Non-small-cell lung cancer	Inhibiting growth	Preclinical	Gao et al. (2022)
		Lung adenocarcinoma	Inhibiting growth and metastasis	Preclinical	Shi et al. (2021)
		Lung adenocarcinoma	Inhibiting growth	Preclinical	Mo et al. (2022)
		Ovarian cancer	Inhibiting growth and metastasis	Preclinical	Li et al. (2021b)
		Glioblastoma	Inhibiting growth	Preclinical	Zhu et al. (2022b)
	Administered nanoliposomal siRNA	Prostate cancer	Inhibiting growth	Preclinical	Pällmann et al. (2021)
	shRNA	Acute myeloid leukemia	Inhibiting growth	Preclinical	Pikman et al. (2016)
		Renal cell carcinoma	Inhibiting growth	Preclinical	Green et al. (2019)
		Lung cancer	Inhibiting growth and stemness	Preclinical	Nishimura et al. (2019)
					Chan et al. (2020)
		Pancreatic cancer	Inhibiting growth	Preclinical	Shang et al. (2021)
SHMT1/2	Inhibitor	T-cell lymphoblastic leukemia	Inhibiting growth	Preclinical	Pikman et al. (2022)
	RZ-2994
	Inhibitor	T-cell lymphoblastic leukemia	Inhibiting growth	Preclinical	Ducker et al. (2017)
	SHIN1
	Inhibitor	T-cell lymphoblastic leukemia	Inhibiting growth	Preclinical	Garcia-Canaveras et al. (2021)
	SHIN1

siRNA, small interfering RNA; shRNA, short hairpin RNA; SHIN1, SHMT, inhibitor.