Figure 1. Example applications of AlphaFold2 beyond single protein structure prediction.

(A) Alphafold2 has shown to be capable of predicting structures for binary protein complexes but predicting structures for larger assemblies remains challenging. A suggested procedure has been to predict the structures for possible sub-complexes and then combine them using superimposition of common subunits (see main text). (B) While AlphaFold2 is trained to predict a single conformation, it has been shown that subsampling of the alignment that serves as the main input, can result in the prediction of different conformations that sometimes resemble known conformations.