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. 2024 Mar 4;7:264. doi: 10.1038/s42003-024-05934-y

Fig. 1. Mechanical injury causes a decrease in CGRP levels in the cornea.

Fig. 1

a Schematic figure showing the method of mechanical injury. The epithelium and superficial stroma were removed using Algerbrush-II. b Assessment of CGRP protein levels using ELISA showed significantly reduced expression following corneal injury on days 1, 3, and 7. c The gene expression levels of the CGRP receptors, calcitonin receptor-like receptor (CLR), receptor activity-modifying protein (RAMP) 1, and RAMP2. RT-PCR showed upregulation of the RAMP1 on day 3 post-injury and returned to normal levels by day 7. (n = 3–5 per group). The data were presented as mean ± standard error of mean (SEM) and comparison is determined by a one-way ANOVA test with pairwise comparison. *p < 0.05, **p < 0.01. (Legend: Circle = naive, Inverted Triangle = Day 1, Square = Day 3, Upright Triangle = Day 7). Figure 1a was created with BioRender.com.