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. 2024 Mar 4;7:264. doi: 10.1038/s42003-024-05934-y

Fig. 2. Topically applied CGRP accelerates corneal epithelial wound closure and reduces corneal opacity.

Fig. 2

a Schematic figure showing the timeline of treatment and clinical examination following injury. b Corneal fluorescein staining was performed to compare the size of epithelial defects in CGRP- and PBS-treated mice at different time points post-injury. c The assessment of the wound area shows that CGRP treatment resulted in a significantly smaller wound area compared to PBS-treated controls across all time points from 24 h to 6 days (n = 9 per group). d Representative slit lamp photographs of PBS and CGRP-treated eyes up to 14 days after injury. The corneas of the PBS-treated controls showed progressive stromal opacification, whereas CGRP treatment showed significantly lower corneal opacity. e The scoring of corneal opacity was performed in a blinded fashion and showed a significantly lower score in CGRP-treated mice (n = 12 per group). The data were represented as mean ± SEM. The statistical significance was determined by unpaired t-test, *p < 0.05, **p < 0.01. (Legend: Pink Square = PBS, Blue Triangle = CGRP). Figure 2a was created with BioRender.com.