Table 2.
Predictors for thrombosis – multivariable Cox regression for risk factors of thrombosis.
| Predictor | HR | 95% CI | P value |
|---|---|---|---|
| Age | 1.04 | 1.02-1.06 | <.001 |
| Gender | 1.04 | 0.47-2.28 | .92 |
| Ethnicity | 1.14 | 0.45-2.85 | .79 |
| MPV/IPF | 1.18 | 0.43-3.28 | .75 |
| Prior splenectomy | 1.87 | 0.72-4.81 | .20 |
| ≥2 cardiac risk factorsa | 2.29 | 0.61-8.63 | .22 |
| ≥2 prior ITP therapies | 1.21 | 1.05-1.38 | <.001 |
| Secondary ITP | 2.63 | 1.20-5.76 | .02 |
| TPO-RA use | 3.15 | 1.45-6.86 | .04 |
Bold indicates significance.
HR, hazard ratio; IPF, immature platelet fraction, ITP, immune thrombocytopenia; MPV, mean platelet volume; TPO-RA, thrombopoietin receptor agonist.
a
Smoking, type 2 diabetes mellitus, hypertension, hypercholesterolemia, family history, prior cardiovascular disease (including acute myocardial infarction, angina, and/or ischemic cerebrovascular accident).