Table 3.
Comparison of the volume of craniofacial bones from E18.5 control, Dhcr7 KO, and Sc5d KO mice.
| Bone | Measurement | MEAN ± STDEV.P (mm3) | Adjusted P Value | Cholesterol | |||||
|---|---|---|---|---|---|---|---|---|---|
| Dhcr7 WT | Dhcr7 KO | Sc5d WT | Sc5d KO | Dhcr7 WT vs Dhcr7 KO | Dhcr7 KO vs Sc5d KO | Sc5d WT vs Sc5d KO | |||
| Premaxilla | Volume | 3.96 ± 0.07 | 3.79 ± 0.05 | 3.95 ± 0.1 | 3.55 ± 0.09 | 0.022 | < .001 | < .001 | Lathosterol |
| Maxilla | Volume | 5.3 ± 0.1 | 4.95 ± 0.1 | 5.19 ± 0.15 | 4.52 ± 0.09 | < .001 | < .001 | < .001 | Cholesterol |
| Palatine | Volume | 0.69 ± 0.03 | 0.63 ± 0.03 | 0.68 ± 0.03 | 0.5 ± 0.01 | 0.004 | < .001 | < .001 | Lathosterol |
| Frontal | Volume | 20.09 ± 0.6 | 27.62 ± 1.43 | 20.06 ± 1.14 | 14.02 ± 0.11 | < .001 | < .001 | < .001 | Lathosterol + Cholesterol |
| Mandible | Volume | 18.13 ± 0.14 | 15.03 ± 0.88 | 17.79 ± 0.41 | 13.16 ± 0.07 | < .001 | < .001 | < .001 | Lathosterol + Cholesterol |