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. 2024 Mar 4;14:5342. doi: 10.1038/s41598-024-55916-7

Table 2.

MIC ranges, MIC50 and MIC90 values for tedizolid and linezolid against the 286 isolates of Nocardia species.

Species (no. of isolates tested) and antimicrobial MIC (μg/ml)
Range MIC50 MIC90
All (286 isolates)
 Tedizolid 0.06–4 0.25 0.5
 Linezolid 0.25–4 2 2
N. farcinica complexa (67 isolates)
 Tedizolid 0.12–0.5 0.5 0.5
 Linezolid 0.5–2 2 2
N. cyriacigeorgica (46 isolates)
 Tedizolid 0.25–1 0.5 0.5
 Linezolid 1–4 2 2
N. nova complexb (45 isolates)
 Tedizolid 0.12–0.5 0.25 0.5
 Linezolid 0.5–2 1 2
N. abscessus complexc (39 isolates)
 Tedizolid 0.12–4 0.25 0.25
 Linezolid 0.5–4 1 2
N. brasiliensis (18 isolates)
 Tedizolid 0.5–1 0.5 1
 Linezolid 2–4 2 4
N. transvalensis complexd (16 isolates)
 Tedizolid 0.25–0.5 0.25 0.5
 Linezolid 1–2 1 2
N. otitidiscaviarum (13 isolates)
 Tedizolid 0.12–0.5 0.5 0.5
 Linezolid 0.5–2 2 2
Other species (42 isolates)
 Tedizolid 0.06–0.5 0.25 0.5
 Linezolid 0.5–2 1 2

aN. farcinica and N. kroppenstedtii were included in the N. farcinica complex, bN. africana, N. aobensis, N. elegans, N. kruczakiae, N. nova, N. vermiculata and N. veterana were included in the N. nova complex, cN. abscessus, N. arthritidis, N. asiatica, N. sputorum, and N. beijingensis were included in the N. abscessus complex, dN. blacklockiae, N. transvalensis, and N. wallacei were included in the N. transvalensis complex.