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. 2024 Feb 20;15:1329011. doi: 10.3389/fphar.2024.1329011

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Copyright © 2024 Ayoub, Gedeon and Munier-Lehmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of the regulation of DNPNB enzyme clustering and purinosome assembly-disassembly under the control of regulatory proteins and signaling pathways. Each circle corresponds to one step of the DNPNB pathway: same color code and numbering as in Table 1. The green filaments represent microtubules. The figure was created with Biorender.com. AMPK, AMP-activated protein kinase; CK2, casein kinase 2; PDK1, 3-phosphoinositide-dependent kinase-1; PI3K, phosphatidylinositol 3-kinase; PI-2P, phosphatidylinositol (4,5)-bisphosphate; PI-3P, phosphatidylinositol (3,4,5)-trisphosphate; PKC, protein kinase C; S6K, p70 ribosomal S6 kinase.