FIGURE 8.

Described protein-protein interactions within the purinosome (Deng et al., 2012; Zhao et al., 2015; Agarwal et al., 2020a; He et al., 2022). Solved 3D-structures of human enzymes (same acronym and color code as in Table 1) have the following PDB accession numbers: 7ALE (PAICS), 4FFX (ADSL), 1PKX (ATIC), 2V40 (hADSS2), 1JCN (hIMPDH1). TrifGART was modeled based on previous published structural data (Welin et al., 2010) and from structures of each of the individual three domains (2QK4 for GARS, 2V9Y for AIRS, 1RBY for GART). The human FGAMS structure was predicted with AlphaFold2 (Jumper et al., 2021). For PPAT, the ortholog from Arabidopsis thaliana (PDB 6LBP; 39% identity) is depicted.