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The proposed model for regulation of PPARγ1 expression by DNA methylation in chicken. NRF1 directly binds to the unmethylated P1 and inhibits PPARγ1 expression (upper panel). When CpG49 alone or in combination with the other CpGs is methylated, NRF1 cannot bind to the methylated promoter P1 and thus leading to derepressed expression of chicken PPARγ1 (lower panel). Open and filled circles represent the unmethylated and methylated CpGs, respectively.
