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. 2024 Mar 5;14(11):7684–7698. doi: 10.1039/d3ra08642a

In vitro α-amylase and α-glucosidase inhibitory potential of compounds 5a–i.

Compound IC50 (μM)
α-Amylase α-Glucosidase
5a >125 41.9 ± 0.78
5b >125 46.6 ± 0.1
5c >125 15.2 ± 0.3
5d >125 54.9 ± 0.9
5e 121.2 ± 1.4 42.8 ± 0.2
5f 42.1 ± 0.2 >125
5g >125 >125
5h 16.4 ± 0.1 31.6 ± 0.4
5i 34.4 ± 0.36 66.9 ± 0.5
Acarbose 24.0 ± 0.9 49.3 ± 1.1