Binding energy of related quinoxaline–isoxazole derivatives and acarbose with α-amylase and α-glucosidase enzymes.

Enzyme	Compound	Binding energya (kcal mol−1)
α-Amylase (2QV4)	5h	−8.9 ± 0.10
	5i	−8.6 ± 0.11
	Acarbose	−7.7 ± 0.11
α-Glucosidase (3TOP)	5a	−8.6 ± 0.15
	5b	−8.6 ± 0.10
	5c	−9.0 ± 0.20
	5e	−8.6 ± 0.10
	5h	−8.7 ± 0.15
	Acarbose	−7.5 ± 0.00

^aSD for n = 3 experiments.