TABLE 2.
Timepoint postdose (h) | Statistics | Rimegepant 75 mg | Rimegepant 300 mg | Moxifloxacin 400 mg |
---|---|---|---|---|
0.5 | LS mean | 1.2 | −0.1 | 8.1 |
90% CI | (−1.05, 3.38) | (−2.29, 2.12) | (5.90, 10.37) | |
1.0 | LS mean | 0.6 | 0.1 | 11.6 |
90% CI | (−1.58, 2.80) | (−2.07, 2.27) | (9.37, 13.78) | |
1.5 | LS mean | −0.7 | 0.9 | 12.0 |
90% CI | (−2.54, 1.22) | (−0.94, 2.79) | (10.10, 13.89) | |
2 | LS mean | −1.4 | −0.5 | 12.8 |
90% CI | (−3.39, 0.55) | (−2.44, 1.47) | (10.80, 14.78) | |
2.5 | LS mean | −0.2 | 0.5 | 12.8 |
90% CI | (−2.42, 2.06) | (−1.72, 2.72) | (10.50, 15.00) | |
3 | LS mean | 0.5 | 0.7 | 13.3 |
90% CI | (−1.62, 2.54) | (−1.33, 2.79) | (11.23, 15.42) | |
3.5 | LS mean | 2.0 | 1.1 | 14.1 |
90% CI | (0.01, 4.06) | (−0.87, 3.16) | (12.10, 16.20) | |
4 | LS mean | 1.0 | 0.9 | 13.5 |
90% CI | (−1.16, 3.10) | (−1.26, 2.98) | (11.33, 15.64) | |
5 | LS mean | 0.9 | 1.5 | 11.1 |
90% CI | (−2.27, 4.15) | (−1.66, 4.69) | (7.88, 14.32) | |
6 | LS mean | 1.2 | 0.9 | 9.4 |
90% CI | (−1.86, 4.27) | (−2.17, 3.92) | (6.27, 12.47) | |
12 | LS mean | −0.3 | −0.9 | 7.5 |
90% CI | (−2.85, 2.30) | (−3.44, 1.68) | (4.89, 10.10) | |
24 | LS mean | 0.9 | 1.6 | 6.7 |
90% CI | (−1.51, 3.31) | (−0.80, 3.98) | (4.23, 9.10) |
Abbreviations: CI, confidence interval; LS, least squares; ΔΔQTcF, placebo‐corrected change‐from‐baseline in Fridericia corrected QT interval.