Table 2.
Univariate and multivariate analysis of clinicopathological variables and TMEM176B expression associated with overall survival
| Parameters | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Gender (male vs female) | 0.910(0.511–1.622) | 0.750 | ||
| Age (years) (< 61 vs ≥ 61) | 1.272 (0.732–2.212) | 0.393 | ||
| Tumor location (upper vs middle + lower) | 1.153 (0.643–2.068) | 0.634 | ||
| Tumor size (cm) (< 6 vs ≥ 6) | 0.824 (0.482–1.408) | 0.479 | ||
| Depth of invasion (T1 + T2 vs T3 + T4) | 1.578 (0.827–3.008) | 0.166 | ||
| Lymph node metastasis (absent vs present) | 3.713 (1.474–9.353) | 0.005a | 3.345 (1.103–10.145) | 0.033a |
| Differentiation (well + moderate vs poor) | 1.648 (0.918–2.957) | 0.094 | ||
| TNM stage (I + II vs III + IV) | 1.967 (1.034–3.739) | 0.039a | 0.844 (0.386–1.843) | 0.670 |
| TMEM176B expression (low vs high) | 2.515 (1.452–4.357) | 0.001a | 2.124 (1.204–3.750) | 0.009a |
aStatistically significant (P < 0.05)