Table 3.
Specific RdRp single nucleotide variants of SARS-CoV-2 correlated with the risk of hospitalization of COVID-19 patients
| SNV | AA | 1st (n = 33) | H (n = 44) | 1st correlated with H | ||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | RR | 95% CI | p-value | ||||
| 14676C > T | P412P | 1 | 25 | 42.10 | 5.27–336.30 | 18.75 | 2.67–131.41 | < 0.0001 |
| 14697C > T | F419F | 0 | 14 | 31.85 | 1.82–557.08 | 21.91 | 1.35–354.54 | 0.0002 |
| 15,096 T > C | N552N | 1 | 14 | 15.93 | 1.84–120.61 | 10.50 | 1.45–75.89 | 0.0013 |
| 15240C > Ta | N600N | 19 | 0 | 119.68 | 6.79–2108.97 | 51.61 | 3.22–825.07 | < 0.0001 |
| 15279C > T | H613H | 2 | 29 | 29.96 | 6.29–142.59 | 10.87 | 2.79–42.37 | < 0.0001 |
1st – number of asymptomatic COVID-19 patients (outpatients), H number of hospitalized (2nd, 3rd and 4th spectrum) COVID-19 patients (inpatients), n number of all COVID-19 patients in the group, OR odds ratio between groups, RR relative risk between groups (1st vs. H), CI Confidence interval, SNV single nucleotide variant, AA Amino acid variant; p-value was measured by Fisher’s exact test, two-sided, p < 0.05, was considered statistically significant; zero values were treated as 0.5; a - negative correlation