Skip to main content
. Author manuscript; available in PMC: 2024 Mar 5.
Published in final edited form as: J Med Chem. 2021 Jul 26;64(15):10934–10950. doi: 10.1021/acs.jmedchem.1c00291

FIGURE 4.

FIGURE 4.

(a) In vitro metabolic stability of DB-60 (20) in the whole blood or liver homogenates from mice. The whole blood and the liver were collected from ICR mice and incubated with the test compounds for the indicated time. The remaining drug levels were quantified (details provided in the methods). P values were calculated using Student’s t-test (GraphPad Prism, v.8.4.1). (b) Effects of DB-60 (20) on LMP2 inhibition and IL-1α release in microglial BV-2 cells stimulated with lipopolysaccharide (LPS) (1 μg/mL). Error bars indicate standard deviation derived from three technical replicates.