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. Author manuscript; available in PMC: 2024 Mar 5.
Published in final edited form as: Nat Chem. 2023 Dec 18;16(2):218–228. doi: 10.1038/s41557-023-01379-8

Extended Data Fig. 3 |. Docking scores and topological polar surface area of C4 and C5 pomalidomide analogs.

Extended Data Fig. 3 |

a–c) Structural docking of pomalidomide analogs with C4 (a) and C5 (b) modifications on the phthalimide ring. Docking score (c) of each pair of modifications on C4 and C5 (paired Wilcoxon test, p = 8.8 × e-05). (d) Distribution of the physicochemical properties of the pomalidomide analog library. The topological polar surface area (TPSA) of each molecule is indicated by color and size (see legend). Note that each dot in the scatter plot represents a pair of compounds with the same modification on C4 and C5 positions, except the SNAr fluoro group. Synthetic routes are represented by different shapes shown in the legend).