Table 2.

Microbiology of bloodstream infection

Variable	Monomicrobial bloodstream infections (n = 3394)	Polymicrobial bloodstream infections (n = 429)	P-value
Gram-positive bacteremia, n(%)	818 (24.1)	236 (55.0)	< 0.001
Staphylococcus aureus	276 (8.1)	34 (7.9)	0.957
Streptococcus pyogenes	6 (0.2)	0 (0.0)	0.823
Streptococcus agalactiae	23 (0.7)	1 (0.2)	0.439
Streptococcus pneumoniae	30 (0.9)	1 (0.2)	0.258
Enterococcus faecalis	54 (1.6)	47 (11.0)	< 0.001
Enterococcus faecium	78 (2.3)	62 (14.5)	< 0.001
Listeria monocytogenes	3 (0.1)	0 (0.0)	1
Corynebacterium striatum	21 (0.6)	6 (1.4)	0.131
Non–S. aureus staphylococcus spp.	141 (4.2)	43 (10.0)	< 0.001
Others	186 (5.5)	82 (19.1)	< 0.001
Gram-negative bacteremia, n(%)	2488 (73.3)	385 (89.7)	< 0.001
Escherichia coli	1256 (37.0)	216 (50.3)	< 0.001
Klebsiella pneumoniae	649 (19.1)	143 (33.3)	< 0.001
Klebsiella oxytoca	36 (1.1)	32 (7.5)	< 0.001
Klebsiella (Enterobacter) aerogenes	26 (0.8)	14 (3.3)	< 0.001
Pseudomonas aeruginosa	136 (4.0)	44 (10.3)	< 0.001
Acinetobacter baumannii	47 (1.4)	15 (3.5)	0.002
Citrobacter spp.	40 (1.2)	28 (6.5)	< 0.001
Enterobacter cloacae	58 (1.7)	35 (8.2)	< 0.001
Proteus spp.	74 (2.2)	24 (5.6)	< 0.001
Serratia marcescens	21 (0.6)	5 (1.2)	0.324
Neisseria meningitidis	0 (0.0)	1 (0.2)	0.219
Haemophilus influenzae	4 (0.1)	0 (0.0)	1
Stenotrophomonas maltophilia	5 (0.1)	2 (0.5)	0.392
Others	137 (4.0)	60 (14.0)	< 0.001
Fungemia, n(%)	67 (2.0)	19 (4.4)	0.002
Candida albicans	31 (0.9)	5 (1.2)	0.807
Candida glabrata	11 (0.3)	9 (2.1)	< 0.001
Candida parapsilosis	5 (0.1)	1 (0.2)	1
Candida tropicalis	13 (0.4)	3 (0.7)	0.576
Cryptococcus neoformans	1 (0.0)	2 (0.5)	0.033
Others	4 (0.1)	1 (0.2)	1
MDR pathogen	1146 (33.8)	200 (46.6)	< 0.001

Spp. Species, MDR Multidrug resistant