Table 2.
Univariate and multivariate analysis of overall survival (OS) in Gastric cancer (GC) patients underwent ESD/ gastrectomy in training cohort
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| P | HR | 95% confidence interval | P | HR | 95% confidence interval | |
|
Gender male/female |
0.219 | 0.847 | 0.648–1.107 | |||
|
Age > 60 y/≤60 y |
0.091 | 1.027 | 0.996–1.059 | |||
|
ASA II/I |
0.316 | 1.172 | 0.861–1.593 | |||
|
ECOG PS 1/0 |
0.123 | 1.234 | 0.945–1.614 | |||
|
Family history of gastric cancer Yes/No |
0.066 | 1.386 | 0.979–1.963 | |||
|
Tumor size > 2.0 cm/≤2.0 cm |
0.024 | 1.569 | 1.062–2.318 | 0.084 | 1.482 | 0.977–2.184 |
|
Differentiation Poorly/ high + Moderately |
0.037 | 1.449 | 1.023–2.054 | 0.021 | 1.514 | 1.142–2.134 |
|
Vascular invasion Yes/No |
< 0.001 | 1.962 | 1.441–2.728 | < 0.001 | 1.778 | 1.389–2.633 |
|
P53 Yes/No |
0.007 | 1.563 | 1.131–2.157 | 0.062 | 1.801 | 0.907–2.243 |
|
Ki-67 ≥ 50%/<50% |
0.283 | 1.186 | 0.863–1.630 | |||
|
Tumor infiltration Submucosa/ Mucosa |
0.024 | 1.274 | 1.033–1.571 | 0.077 | 1.189 | 0.968–1.355 |
|
MSI status MSI-high/ (MSS/MSI-low) |
0.353 | 0.856 | 0.613–1.195 | |||
|
Treatment method ESD/ gastrectomy |
0.133 | 1.121 | 0.981–1.235 | |||
ESD: Endoscopic Submucosal Dissection; ASA:American Society of Anesthesiologists;ECOG:Eastern Cooperative Oncology Group; CTC: Circulating Tumor Cells
TNM stages are according to AJCC 8th edition